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Symptoms, diagnosis and causes of wegener's granulomatosis

Symptoms, diagnosis and causes of wegener's granulomatosis

Symptoms, diagnosis and causes of wegener's granulomatosis

Symptoms, diagnosis and causes of wegener's granulomatosis

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Wegener granulomatosis (WG) is a multisystem autoimmune disease in which inflammation and in small and medium-sized blood vessels causes tissue damage.

Incidence, age and sex

The annual incidence of WG is 5-10 per million. Men are more likely to be affected with a male-to-female ratio of 1.5:1. Women are more likely to have limited disease. Onset of WG may occur at any age; patients typically present at age 35-55 years. WG is rare in childhood.

Signs and symptoms

Nonspecific constitutional complaints: like fevers, night sweats ,fatigue, lethargy, loss of appetite & weight loss may occur. The other common symptoms are epistaxis, nasal crusting ,sinusitis, haemoptysis, musosal ulceration and deafness due to serous otitis media.

Complications

The most common ocular abnormality is proptosis which may cause diplopia loss of vision due to optic nerve compression .They may also develop lung disease,skin ulcers,renal disease & neurological involvement.Untreated nasal disease ultimately leads to destruction of bone and cartilage. Migratory pulmonary infiltrates and nodules occur in 50% of patients. A minority of patients present with glomerulonephritis.

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