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DNA paternity testing is a scientific process that can positively identify relationships between people from their DNA. Most commonly it is used to establish if a man is the true biological father of a child. DNA paternity testing is also often referred to simply as a DNA test, a paternity test or DNA testing.
Y-chromosome DNA testing
DNA is organised into 46 chromosomes, 23 inherited from their mother and 23 inherited from their father. One chromosome, called the Y-chromosome, is only present in men and is transmitted from a father to his son unchanged. Y-chromosome testing involves the analysis of 17 genetic markers (called STRs) on the Y chromosome to produce a YSTR profile.
Results from a Y-STR investigation will report either that:
OR
Common applications of the Y-chromosome test:
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Genealogy: The Y-chromosome test can be used to provide evidence linking individuals to a common male line as they share the same Y-STR profile, or it can provide proof that they are not related. This type of test is often used in surname projects which involve large groups of individuals with a common surname who are interested in researching their ancestors.
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Male relationship testing: In cases where the alleged father is unavailable for testing or deceased, a male can be tested against other potential male relatives such as his uncles (his father's brother's), his grandfather or his grandfather's brothers who share the same alleged male line.
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Sibling testing: Y-chromosome testing can be used as an alternative (or additional) test, where both children are male, to determine if they could share the same father.
Note: Y STR testing can in some instances conclusively confirm that two people do not share a common male relative. Alternatively it can provide very useful information to support a common male inheritance - but the statistical significance of the results in such cases will not approach the levels achieved in standard paternity testing. Indeed, Y STR testing should not be regarded as an alternative to standard paternity testing, since all male blood relatives in a family will have the same YSTR profile.
For further information on the work of the Human Genetics Commission and the Human Tissue Act visit the HGC’s website www.hgc.gov.uk.
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