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'Suicide' gene offers hope of targeted ovarian cancer treatment

A Study has developed a cancer treatment that uses a 'suicide' gene to fight ovarian cancer that is advanced and has recurred after radiotherapy and chemotherapy.

Using a nanoparticle to deliver the DNA-encoding diphtheria toxin to the site of the tumour in mice, scientists found the cancer was less likely to grow.

Tumour volumes were measured before and after treatment and those that were treated grew two-fold, while those that were not injected with the suicide gene grew by four or six times.

It is expected that the research will now be carried out in trials on human within the next two years.

Lead researcher Dr Janet Sawicki, professor at the Lankenau Institute for Medical Research, commented: "This report is definitely a reason to hope. We now have a potential new therapy for the treatment of advanced ovarian cancer that has promise for targeting tumor cells and leaving healthy cells healthy."

The risk of developing ovarian cancer increases as a woman gets older and is the fifth leading cause of death due to cancer in women.

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'Suicide' gene offers hope of targeted ovarian cancer treatment
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