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Alzheimer's Disease

What is Alzheimer's disease?

Alzheimer's disease is the most common cause of dementia, affecting around 417,000 people in the UK.

 

Alzheimer's disease, was first described by a German neurologist Alois Alzheimer as a physical disease affecting the brain.

 

During the course of the disease, 'plaques' and 'tangles' develop in the structure of the brain, leading to the death of brain cells. People with Alzheimer's also have a shortage of some important chemicals in their brains. These chemicals are involved with the transmission of messages within the brain.

 

Alzheimer's is a progressive disease, which means that gradually, over time, more parts of the brain are damaged. As this happens, the symptoms become more severe.

 

Alzheimer's disease symptoms

People in the early stages of Alzheimer's disease may experience lapses of memory and have problems finding the right words. As the disease progresses, they may become confused, and frequently forget the names of people, places, appointments and recent events experience mood swings. They may feel sad or angry. They may feel scared and frustrated by their increasing memory loss and become more withdrawn, due either to a loss of confidence or to communication problems.

 

As the disease progresses, people with Alzheimer's will need more support from those who care for them. Eventually, they will need help with all their daily activities.

 

While there are some common symptoms of Alzheimer's disease, it is important to remember that everyone is unique. No two people are likely to experience Alzheimer's disease in the same way.

 

Mild cognitive impairment

Recently, some doctors have begun to use the term 'mild cognitive impairment' (MCI) when an individual has difficulty remembering things or thinking clearly but the symptoms are not severe enough to warrant the diagnosis of Alzheimer's disease. Recent research has shown that a small number of individuals with MCI have an increased risk of progressing to Alzheimer's disease. However, the conversion rate from MCI to Alzheimer's is small (about 10-15 per cent), and consequently a diagnosis of MCI does not always mean that the person will go on to develop Alzheimer's.

 

What causes Alzheimer's disease?

So far, no one single factor has been identified as a cause for Alzheimer's disease. It is likely that a combination of factors, including age, genetic inheritance, environmental factors, diet and overall general health, are responsible. In some people, the disease may develop silently for many years before symptoms appear and the onset of clinical disease may require a trigger.

 

Age

Age is the greatest risk factor for dementia. Dementia affects one in 14 people over the age of 65 and one in six over the age of 80. However, Alzheimer's is not restricted to elderly people: in the UK, there are 15,000 people under the age of 65 with dementia, although this figure is likely to be an underestimate.

 

Genetic inheritance

Many people fear that they may inherit Alzheimer's disease, and scientists are currently investigating the genetic background to Alzheimer's.

 

We do know that there are a few families where there is a very clear inheritance of the disease from one generation to the next. This is often in families where the disease appears relatively early in life.

 

In the vast majority of cases, however, the effect of inheritance seems to be small. If a parent or other relative has Alzheimer's disease, your own chances of developing the disease are only a little higher than if there were no cases of Alzheimer's in the immediate family.

 

However, carriers of the ApoE4 gene variant have a much higher chance of developing Alzheimer's disease.

 

Environmental factors

The environmental factors that may contribute to the onset of Alzheimer's disease have yet to be identified. A few years ago, there were concerns that exposure to aluminium might cause Alzheimer's disease. However, these fears have largely been discounted.

 

Other factors

Because of the difference in their chromosomal make-up, people with Down's syndrome who live into their 50s and 60s may develop Alzheimer's disease. People who have had severe head or whiplash injuries also appear to be at increased risk of developing dementia. Boxers who receive continual blows to the head are at risk too. Research has also shown that people who smoke, and those who have high blood pressure or high cholesterol levels also increase their risk of developing Alzheimer's.

 

Getting a diagnosis

If you are concerned about your own health, or the health of someone close to you, it is important to seek help from a GP, who may refer you on to a Consultant Neurologist. An early diagnosis will help you plan for the future and enable the person with dementia to benefit from the treatments that are now available and help you identify sources of advice and support.

 

There is no straightforward test for Alzheimer's disease or for any other cause of dementia. A diagnosis is usually made by excluding other causes which can present similar symptoms, such as infections, vitamin deficiency, thyroid problems, brain tumours, depression and the side-effects of drugs.

 

Tests

The person being tested will usually be given a blood test and a full physical examination to rule out or identify any other medical problems. The person's memory will be assessed, initially with questions about recent events and past memories. Their memory and thinking skills may also be assessed in detail by a psychologist. A brain scan may be carried out to give some clues about the changes taking place in the person's brain. There are a number of different types of scan, including computerised tomography (CT) and magnetic resonance imaging (MRI).

 

Treatment

There is currently no cure for Alzheimer's disease. However, some drug treatments are available that can ameliorate the symptoms or slow down the disease progression in some people.

 

People with Alzheimer's have been shown to have a shortage of the chemical acetylcholine in their brains. The drugs Aricept, Exelon and Reminyl (trade names for the drugs donepezil hydrochloride, rivastigmine and galantamine, respectively) work by maintaining existing supplies of acetylcholine. These drugs are available to people in the moderate stages of dementia, and at your GP and Specialists discretion, usually for people in the early stages.

 

A drug called Ebixa (trade name for the drug memantine) was launched in the UK in 2002. This drug works in a different way to the other three − it prevents the excess entry of calcium ions into brain cells. Excess calcium in the brain cells damages them and prevents them from receiving messages from other brain cells. Ebixa is the only drug that is suitable for use in people in the middle to later stages of dementia. Side-effects may include hallucinations, confusion, dizziness, headaches and tiredness.

 

These drugs are not a cure, but they may stabilise some of the symptoms of Alzheimer's disease for a limited period of time. Some evidence suggests that dietary supplements of antioxidants, such as vitamins D and C, can reduce the prevalence of Alzheimer's. However, more recent studies have been unable to repeat this finding and further work is necessary to clarify the role that dietary supplements have in Alzheimer's disease.


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Brain and neurology guide: conditions and treatments